Nanodiamonds Cross Blood-Brain Barrier to Image Inside, Deliver Drugs

The blood-brain barrier is nearly impenetrable to most drugs and contrast agents, making it difficult to diagnose and treat diseases afflicting the brain. Researchers at the Max Planck Institute for Polymer Research have now developed a way of using nanodiamonds coated with a biopolymer to penetrate through the blood-brain barrier and deliver therapies, as well as create the possibility for a novel form of brain imaging.

Nanodiamonds, being nothing but carbon, are quite biocompatible, but they’re difficult to work with since they’re non-reactive and won’t bind to most things. By coating nanodiamonds with a polymer based on the serum albumin protein, the compound can be made to bind to drugs and is readily absorbed through the blood-brain barrier.

To make the nanodiamonds useful for brain imaging, the team had single-atom defects created within by replacing a carbon atom with one of nitrogen. This made the tiny diamonds flicker radically when exposed to laser light, but it also made the nanodiamonds visible on MRI scans.

The technique has already been tested in lab mice, without any noticeable damage to the blood brain barrier, but the technology is still in the very early stages and there’s a lot of work left before we’ll be using nanodiamonds for neuro applications in the clinical space.

Study in journal Small: Unraveling In Vivo Brain Transport of Protein‐Coated Fluorescent Nanodiamonds

Via: Max Planck Institute for Polymer Research